Many individuals don’t get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, due to intestinal or liver dysfunction, or because genetic makeup makes it difficult to convert folic acid into active 5-MTHF. A deficiency of folic acid has been linked to low-birth-weight infants and neural tube defects, folic acid supplementation is recommended for all women of childbearing age. 5-MTHF also contributes to the production of serotonin, melatonin, dopamine, adrenaline, and noradrenaline and supplementation supports healthy mood.
Note: 1 mg of 5-MTHF is recommended for fetal support during pregnancy. It is important for a woman of childbearing age to get enough folic acid and not just those women who are planning to become pregnant. Folic acid intake is mostly important before conception and during early pregnancy, the biggest need is during the first trimester – when a woman might not even know she is pregnant. Supplementing with the active form of folic acid – 5-MTHF (L-5 Methyltetrahydrofolate) is always preferable.
Acting with vitamin B12, 5-MTHF functions as a methyl group donor, thereby facilitating the conversion of the amino acid homocysteine to methionine. Elevated homocysteine levels is a risk factor for a number of undesirable health conditions. Methyl group donation is vital to many biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.
Interactions: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate’s anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Disclaimer: The information on Confidere & Co’s website is not intended to self diagnose, treat, cure or prevent any disease. Always consult with a health care practitioner or doctor if you have any pre-existing medical condition or currently taking medication. Confidere & Co recommends you always read the label, warnings and interactions before use. Follow the directions and only use as directed. If symptoms persist please consult with a health care practitioner.